Optogenetic induction of alpha-synuclein aggregation in human dopaminergic neurons to model Parkinson’s disease pathology

Alpha-synuclein (α-syn) aggregation is a principal factor in Parkinson’s disease (PD) onset. Here, we present a protocol for optogenetic induction of α-syn aggregation in human midbrain dopaminergic (mDA) neurons, facilitating a detailed PD pathology study. We describe steps for nucleofection of the...

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Detalles Bibliográficos
Autores principales: Ra, Eun A., Kim, Min Seong, Lee, Gabsang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522986/
https://www.ncbi.nlm.nih.gov/pubmed/37742181
http://dx.doi.org/10.1016/j.xpro.2023.102609

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10522986/
https://www.ncbi.nlm.nih.gov/pubmed/37742181
http://dx.doi.org/10.1016/j.xpro.2023.102609

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