Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK

INTRODUCTION: Cytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of increased inhibitory receptors, impaired cytokine production and a distinct transcriptional profile. Evidence from immune checkpoint block...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ling, Zhao, Manzhi, Kiernan, Caoimhe H., Castro Eiro, Melisa D., van Meurs, Marjan, Brouwers-Haspels, Inge, Wilmsen, Merel E. P., Grashof, Dwin G. B., van de Werken, Harmen J. G., Hendriks, Rudi W., Mueller, Yvonne M., Katsikis, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523025/
https://www.ncbi.nlm.nih.gov/pubmed/37771591
http://dx.doi.org/10.3389/fimmu.2023.1201415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523025/
https://www.ncbi.nlm.nih.gov/pubmed/37771591
http://dx.doi.org/10.3389/fimmu.2023.1201415

Ejemplares similares