Fishing for Catalysis: Experimental Approaches to Narrowing Search Space in Directed Evolution of Enzymes

[Image: see text] Directed evolution has transformed protein engineering offering a path to rapid improvement of protein properties. Yet, in practice it is limited by the hyper-astronomic protein sequence search space, and approaches to identify mutagenic hot spots, i.e., locations where mutations a...

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Detalles Bibliográficos
Autores principales: Marshall, Liam R., Bhattacharya, Sagar, Korendovych, Ivan V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523367/
https://www.ncbi.nlm.nih.gov/pubmed/37772192
http://dx.doi.org/10.1021/jacsau.3c00315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523367/
https://www.ncbi.nlm.nih.gov/pubmed/37772192
http://dx.doi.org/10.1021/jacsau.3c00315

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