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Fishing for Catalysis: Experimental Approaches to Narrowing Search Space in Directed Evolution of Enzymes
[Image: see text] Directed evolution has transformed protein engineering offering a path to rapid improvement of protein properties. Yet, in practice it is limited by the hyper-astronomic protein sequence search space, and approaches to identify mutagenic hot spots, i.e., locations where mutations a...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523367/ https://www.ncbi.nlm.nih.gov/pubmed/37772192 http://dx.doi.org/10.1021/jacsau.3c00315 |