The Leu/Val(6.51) Side Chain of Cannabinoid Receptors Regulates the Binding Mode of the Alkyl Chain of Δ(9)-Tetrahydrocannabinol

[Image: see text] (−)-Δ(9)-trans-tetrahydrocannabinol (THC), which is the principal psychoactive constituent of Cannabis, mediates its action by binding to two members of the G-protein-coupled receptor (GPCR) family: the cannabinoid CB(1) (CB(1)R) and CB(2) (CB(2)R) receptors. Molecular dynamics sim...

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Detalles Bibliográficos
Autores principales: Llinas del Torrent, Claudia, Raïch, Iu, Gonzalez, Angel, Casajuana-Martin, Nil, Lillo, Jaume, Rebassa, Joan Biel, Ferreiro-Vera, Carlos, Sánchez de Medina, Verónica, Franco, Rafael, Navarro, Gemma, Pardo, Leonardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523433/
https://www.ncbi.nlm.nih.gov/pubmed/37644761
http://dx.doi.org/10.1021/acs.jcim.3c01054

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523433/
https://www.ncbi.nlm.nih.gov/pubmed/37644761
http://dx.doi.org/10.1021/acs.jcim.3c01054

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