Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy

Mammalian FNDC5 encodes a protein precursor of Irisin, which is important for exercise-dependent regulation of whole-body metabolism. In a genetic screen in Drosophila, we identified Iditarod (Idit), which shows substantial protein homology to mouse and human FNDC5, as a regulator of autophagy actin...

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Detalles Bibliográficos
Autores principales: Cobb, Tyler, Hwang, Irene, Soukar, Michael, Namkoong, Sim, Cho, Uhn-Soo, Safdar, Maryam, Kim, Myungjin, Wessells, Robert J., Lee, Jun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523451/
https://www.ncbi.nlm.nih.gov/pubmed/37722048
http://dx.doi.org/10.1073/pnas.2220556120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523451/
https://www.ncbi.nlm.nih.gov/pubmed/37722048
http://dx.doi.org/10.1073/pnas.2220556120

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