Cargando…

Iditarod, a Drosophila homolog of the Irisin precursor FNDC5, is critical for exercise performance and cardiac autophagy

Mammalian FNDC5 encodes a protein precursor of Irisin, which is important for exercise-dependent regulation of whole-body metabolism. In a genetic screen in Drosophila, we identified Iditarod (Idit), which shows substantial protein homology to mouse and human FNDC5, as a regulator of autophagy actin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cobb, Tyler, Hwang, Irene, Soukar, Michael, Namkoong, Sim, Cho, Uhn-Soo, Safdar, Maryam, Kim, Myungjin, Wessells, Robert J., Lee, Jun Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523451/ https://www.ncbi.nlm.nih.gov/pubmed/37722048 http://dx.doi.org/10.1073/pnas.2220556120

Ejemplares similares

Irisin Precursor FNDC5 and Glycemic Control in Patients With Type 2 Diabetes
por: Lima Mágero, Felipe Rodrigues, et al.
Publicado: (2021)

FNDC5/Irisin: Physiology and Pathophysiology
por: Waseem, Rashid, et al.
Publicado: (2022)

Expression of Irisin/FNDC5 in Breast Cancer
por: Cebulski, Kamil, et al.
Publicado: (2022)

Progress and Challenges in the Biology of FNDC5 and Irisin
por: Maak, Steffen, et al.
Publicado: (2021)

Irisin/FNDC5: A participant in camel metabolism
por: Kirat, Doaa, et al.
Publicado: (2021)

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine
por: Roca-Rivada, Arturo, et al.
Publicado: (2013)

The diagnostic value of FNDC5/Irisin in renal Cell Cancer
por: Altay, Diler Us, et al.
Publicado: (2018)

Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment
por: Peng, Jin, et al.
Publicado: (2022)

Irisin and FNDC5 in retrospect: An exercise hormone or a transmembrane receptor?
por: Erickson, Harold P
Publicado: (2013)

Exercise-induced FNDC5/irisin protects nucleus pulposus cells against senescence and apoptosis by activating autophagy
por: Zhou, Wenxian, et al.
Publicado: (2022)

New insights into the cellular activities of Fndc5/Irisin and its signaling pathways
por: Rabiee, Farzaneh, et al.
Publicado: (2020)

FNDC5/Irisin System in Neuroinflammation and Neurodegenerative Diseases: Update and Novel Perspective
por: Pignataro, Patrizia, et al.
Publicado: (2021)

Evaluation of Serum Concentration of the Myokine Irisin (FNDC5) in Patients with Age-Related
por: Turgut, Burak, et al.
Publicado: (2021)

Low FNDC5/Irisin expression is associated with aggressive phenotypes in gastric cancer
por: Xu, Luyun, et al.
Publicado: (2022)

Brain FNDC5/Irisin Expression in Patients and Mouse Models of Major Depression
por: Lima-Filho, Ricardo, et al.
Publicado: (2023)

The Role of Irisin/FNDC5 Expression and Its Serum Level in Breast Cancer
por: Cebulski, Kamil, et al.
Publicado: (2023)

Locus Characterization and Gene Expression of Bovine FNDC5: Is the Myokine Irisin Relevant in Cattle?
por: Komolka, Katrin, et al.
Publicado: (2014)

Lack of Adipocyte-Fndc5/Irisin Expression and Secretion Reduces Thermogenesis and Enhances Adipogenesis
por: Pérez-Sotelo, D., et al.
Publicado: (2017)

Association of Irisin/FNDC5 with ERRα and PGC-1α Expression in NSCLC
por: Nowińska, Katarzyna, et al.
Publicado: (2022)

Time-dependent unloading effects on muscle and bone and involvement of FNDC5/irisin axis
por: Sanesi, Lorenzo, et al.
Publicado: (2023)

SNPs in FNDC5 (irisin) are associated with obesity and modulation of glucose and lipid metabolism in Saudi subjects
por: Al-Daghri, Nasser M., et al.
Publicado: (2016)

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
por: Lourenco, Mychael V., et al.
Publicado: (2019)

FNDC5/Irisin – Their Role in the Nervous System and as a Mediator for Beneficial Effects of Exercise on the Brain
por: Wrann, Christiane D.
Publicado: (2015)

Sestrin regulates acute chill coma recovery in Drosophila melanogaster
por: Cobb, Tyler, et al.
Publicado: (2021)

Comparative Genomic Characterization of Buffalo Fibronectin Type III Domain Proteins: Exploring the Novel Role of FNDC5/Irisin as a Ligand of Gonadal Receptors
por: Wu, Siwen, et al.
Publicado: (2021)

Can Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?
por: Reisi, Jalil, et al.
Publicado: (2016)

Exercise-induced myokine FNDC5/irisin functions in cardiovascular protection and intracerebral retrieval of synaptic plasticity
por: Zhou, Xin, et al.
Publicado: (2019)

Expression of Irisin/FNDC5 in Cancer Cells and Stromal Fibroblasts of Non-Small Cell Lung Cancer
por: Nowinska, Katarzyna, et al.
Publicado: (2019)

Octopamine Rescues Endurance and Climbing Speed in Drosophila Clk(out) Mutants with Circadian Rhythm Disruption
por: Safdar, Maryam, et al.
Publicado: (2023)

The effects of genetic background on exercise performance in Drosophila
por: Damschroder, Deena, et al.
Publicado: (2020)

FNDC5 expression and circulating irisin levels are modified by diet and hormonal conditions in hypothalamus, adipose tissue and muscle
por: Varela-Rodríguez, B. M., et al.
Publicado: (2016)

FNDC5/irisin improves the therapeutic efficacy of bone marrow-derived mesenchymal stem cells for myocardial infarction
por: Deng, Jingyu, et al.
Publicado: (2020)

Associations of Circulating Irisin with FNDC5 Expression in Fat and Muscle in Type 1 and Type 2 Diabetic Mice
por: Jiang, Songling, et al.
Publicado: (2021)

Variation in mobility and exercise adaptations between Drosophila species
por: Cobb, Tyler, et al.
Publicado: (2020)

Irisin and Autophagy: First Update
por: Pesce, Mirko, et al.
Publicado: (2020)

Serum and Adipose Tissue mRNA Levels of ATF3 and FNDC5/Irisin in Colorectal Cancer Patients With or Without Obesity
por: Zhu, Huijuan, et al.
Publicado: (2018)

NAD(+)-boosting therapy alleviates nonalcoholic fatty liver disease via stimulating a novel exerkine Fndc5/irisin
por: Li, Dong-Jie, et al.
Publicado: (2021)

Dietary Intervention, When Not Associated With Exercise, Upregulates Irisin/FNDC5 While Reducing Visceral Adiposity Markers in Obese Rats
por: Furino, Vanessa de Oliveira, et al.
Publicado: (2021)

CircRNA AFF4 induced by KDM1A promotes osteogenic differentiation through FNDC5/Irisin pathway
por: Liu, Ansong, et al.
Publicado: (2022)

FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction
por: Wang, Tao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kdbeigogep32uifbvq5p4eigfd