Causal ALS genes impact the MHC class II antigen presentation pathway

Mutations in RNA/DNA-binding proteins cause amyotrophic lateral sclerosis (ALS), but the underlying disease mechanisms remain unclear. Here, we report that a set of ALS-associated proteins, namely FUS, EWSR1, TAF15, and MATR3, impact the expression of genes encoding the major histocompatibility comp...

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Detalles Bibliográficos
Autores principales: Chi, Binkai, Öztürk, Muhammet M., Paraggio, Christina L., Leonard, Claudia E., Sanita, Maria E., Dastpak, Mahtab, O’Connell, Jeremy D., Coady, Jordan A., Zhang, Jiuchun, Gygi, Steven P., Lopez-Gonzalez, Rodrigo, Yin, Shanye, Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523463/
https://www.ncbi.nlm.nih.gov/pubmed/37722062
http://dx.doi.org/10.1073/pnas.2305756120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523463/
https://www.ncbi.nlm.nih.gov/pubmed/37722062
http://dx.doi.org/10.1073/pnas.2305756120

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