Coenzyme Q10 trapping in mitochondrial complex I underlies Leber’s hereditary optic neuropathy

How does a single amino acid mutation occurring in the blinding disease, Leber’s hereditary optic neuropathy (LHON), impair electron shuttling in mitochondria? We investigated changes induced by the m.3460 G>A mutation in mitochondrial protein ND1 using the tools of Molecular Dynamics and Free En...

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Detalles Bibliográficos
Autores principales: Fuller, Jack T., Barnes, Steven, Sadun, Lorenzo A., Ajmera, Pujan, Alexandrova, Anastassia N., Sadun, Alfredo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523484/
https://www.ncbi.nlm.nih.gov/pubmed/37733737
http://dx.doi.org/10.1073/pnas.2304884120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523484/
https://www.ncbi.nlm.nih.gov/pubmed/37733737
http://dx.doi.org/10.1073/pnas.2304884120

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