Cargando…

Coenzyme Q10 trapping in mitochondrial complex I underlies Leber’s hereditary optic neuropathy

How does a single amino acid mutation occurring in the blinding disease, Leber’s hereditary optic neuropathy (LHON), impair electron shuttling in mitochondria? We investigated changes induced by the m.3460 G>A mutation in mitochondrial protein ND1 using the tools of Molecular Dynamics and Free En...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuller, Jack T., Barnes, Steven, Sadun, Lorenzo A., Ajmera, Pujan, Alexandrova, Anastassia N., Sadun, Alfredo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Physical Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523484/ https://www.ncbi.nlm.nih.gov/pubmed/37733737 http://dx.doi.org/10.1073/pnas.2304884120

Ejemplares similares

Leber's hereditary optic neuropathy: Shifting our attention to the macula
por: Asanad, Samuel, et al.
Publicado: (2018)

Hormone replacement therapy in Leber's hereditary optic neuropathy: Accelerated visual recovery in vivo
por: Fantini, Michele, et al.
Publicado: (2018)

A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy
por: Frousiakis, Starleen E., et al.
Publicado: (2014)

Improving the visual outcome in Leber's hereditary optic neuropathy: Framework for the future
por: Asanad, Samuel, et al.
Publicado: (2019)

Gene Therapies for the Treatment of Leber Hereditary Optic Neuropathy
por: Sahel, José-Alain, et al.
Publicado: (2021)

Solutions to a Radical Problem: Overview of Current and Future Treatment Strategies in Leber’s Hereditary Opic Neuropathy
por: Spiegel, Samuel J., et al.
Publicado: (2022)

Secondary Post-Geniculate Involvement in Leber’s Hereditary Optic Neuropathy
por: Rizzo, Giovanni, et al.
Publicado: (2012)

Efficient mitochondrial biogenesis drives incomplete penetrance in Leber’s hereditary optic neuropathy
por: Giordano, Carla, et al.
Publicado: (2014)

Phosphorylated neurofilament heavy chain is a marker of neurodegeneration in Leber hereditary optic neuropathy (LHON)
por: Guy, John, et al.
Publicado: (2008)

Changes in Choroidal Thickness follow the RNFL Changes in Leber’s Hereditary Optic Neuropathy
por: Borrelli, Enrico, et al.
Publicado: (2016)

Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
por: Danese, Alberto, et al.
Publicado: (2022)

Benefit of Stimulus Size V Perimetry for Patients With a Dense Central Scotoma From Leber's Hereditary Optic Neuropathy
por: Mejia-Vergara, Alvaro J., et al.
Publicado: (2021)

Medical Management of Hereditary Optic Neuropathies
por: La Morgia, Chiara, et al.
Publicado: (2014)

Natural history of patients with Leber hereditary optic neuropathy—results from the REALITY study
por: Yu-Wai-Man, Patrick, et al.
Publicado: (2021)

Choroidal thickness and the retinal ganglion cell complex in chronic Leberʼs hereditary optic neuropathy: a prospective study using swept-source optical coherence tomography
por: Darvizeh, Fatemeh, et al.
Publicado: (2019)

Leber’s Hereditary Optic Neuropathy: The Mitochondrial Connection Revisited
por: Abu-Amero, Khaled K.
Publicado: (2011)

Rare Primary Mitochondrial DNA Mutations and Probable Synergistic Variants in Leber’s Hereditary Optic Neuropathy
por: Achilli, Alessandro, et al.
Publicado: (2012)

Leber hereditary optic neuropathy: current perspectives
por: Meyerson, Cherise, et al.
Publicado: (2015)

Leber’s hereditary optic neuropathy - Case report
por: Iorga, Raluca Eugenia, et al.
Publicado: (2018)

Leber’s Hereditary Optic Neuropathy – Case Discussion
por: Culea, Cristina, et al.
Publicado: (2019)

Arterial sheathing in Leber hereditary optic neuropathy
por: Zhou, Henry W., et al.
Publicado: (2022)

Clinical Overview of Leber Hereditary Optic Neuropathy
por: Stramkauskaitė, Almina, et al.
Publicado: (2022)

Leber’s Hereditary Optic Neuropathy and Hypertrophic Cardiomyopathy
por: Hey, Thomas Morris, et al.
Publicado: (2022)

Developments in the Treatment of Leber Hereditary Optic Neuropathy
por: Chen, Benson S., et al.
Publicado: (2022)

Identification of novel mitochondrial mutations in Leber’s hereditary optic neuropathy
por: Kumar, Manoj, et al.
Publicado: (2010)

Leber's hereditary optic neuropathy with 3460 mitochondrial DNA mutation.
por: Hwang, Jeong-Min, et al.
Publicado: (2002)

Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy
por: Manickam, Agaath Hedina, et al.
Publicado: (2017)

Long-Term Follow-Up After Unilateral Intravitreal Gene Therapy for Leber Hereditary Optic Neuropathy: The RESTORE Study
por: Biousse, Valérie, et al.
Publicado: (2021)

Gene–environment interactions in Leber hereditary optic neuropathy
por: Kirkman, Matthew Anthony, et al.
Publicado: (2009)

Leber’s hereditary optic neuropathy is multiorgan not mono-organ
por: Finsterer, Josef, et al.
Publicado: (2016)

The Progress of Gene Therapy for Leber's Optic Hereditary Neuropathy
por: Zhang, Yong, et al.
Publicado: (2018)

Leber hereditary optic neuropathy: bridging the translational gap
por: Jurkute, Neringa, et al.
Publicado: (2017)

Leber’s Hereditary Optic Neuropathy – Reply Letter to the Editor
por: Manole, Cristina, et al.
Publicado: (2020)

Leber Hereditary Optic Neuropathy: Review of Treatment and Management
por: Hage, Rabih, et al.
Publicado: (2021)

Mutations for Leber hereditary optic neuropathy in patients with alcohol and tobacco optic neuropathy
por: Amaral-Fernandes, Marcela Scabello, et al.
Publicado: (2011)

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy
por: Wong, Raymond C.B., et al.
Publicado: (2017)

Mitochondrial DNA Variation of Leber’s Hereditary Optic Neuropathy in Western Siberia
por: Starikovskaya, Elena, et al.
Publicado: (2019)

Leber’s Hereditary Optic Neuropathy: the roles of mitochondrial transfer RNA variants
por: Ding, Yu, et al.
Publicado: (2021)

Persistence of the treatment effect of idebenone in Leber’s hereditary optic neuropathy
por: Klopstock, T., et al.
Publicado: (2013)

MRI in Leber's hereditary optic neuropathy: the relationship to multiple sclerosis
por: Matthews, Lucy, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2s7n9385511f3qs1mc8b2850go