Human engineered cardiac tissue model of hypertrophic cardiomyopathy recapitulates key hallmarks of the disease and the effect of chronic mavacamten treatment

Introduction: The development of patient-specific induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) offers an opportunity to study genotype-phenotype correlation of hypertrophic cardiomyopathy (HCM), one of the most common inherited cardiac diseases. However, immaturity of the iPSC-CMs...

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Detalles Bibliográficos
Autores principales: Wang, Kai, Schriver, Brian J., Aschar-Sobbi, Roozbeh, Yi, Alex Y., Feric, Nicole T., Graziano, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523579/
https://www.ncbi.nlm.nih.gov/pubmed/37771571
http://dx.doi.org/10.3389/fbioe.2023.1227184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523579/
https://www.ncbi.nlm.nih.gov/pubmed/37771571
http://dx.doi.org/10.3389/fbioe.2023.1227184

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