The gut metabolite 3-hydroxyphenylacetic acid rejuvenates spermatogenic dysfunction in aged mice through GPX4-mediated ferroptosis

BACKGROUND: Aging-related fertility decline is a prevalent concern globally. Male reproductive system aging is mainly characterized by a decrease in sperm quality and fertility. While it is known that intestinal physiology changes with age and that microbiota is shaped by physiology, the underlying...

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Detalles Bibliográficos
Autores principales: Jin, Zirun, Yang, Yuzhuo, Cao, Yalei, Wen, Qi, Xi, Yu, Cheng, Jianxing, Zhao, Qiancheng, Weng, Jiaming, Hong, Kai, Jiang, Hui, Hang, Jing, Zhang, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523725/
https://www.ncbi.nlm.nih.gov/pubmed/37752615
http://dx.doi.org/10.1186/s40168-023-01659-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10523725/
https://www.ncbi.nlm.nih.gov/pubmed/37752615
http://dx.doi.org/10.1186/s40168-023-01659-y

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