Cargando…

Exploring the inhibitory potential of the antiarrhythmic drug amiodarone against Clostridioides difficile toxins TcdA and TcdB

The intestinal pathogen Clostridioides difficile is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis in humans. The symptoms of C. difficile-associated diseases (CDADs) are directly associated with the pathogen’s toxins TcdA and TcdB, which enter host cells and inacti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Schumacher, Judith, Nienhaus, Astrid, Heber, Sebastian, Matylitsky, Jauheni, Chaves-Olarte, Esteban, Rodríguez, César, Barth, Holger, Papatheodorou, Panagiotis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10524773/ https://www.ncbi.nlm.nih.gov/pubmed/37749884 http://dx.doi.org/10.1080/19490976.2023.2256695

Ejemplares similares

Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol
por: Heber, Sebastian, et al.
Publicado: (2022)

The Compound U18666A Inhibits the Intoxication of Cells by Clostridioides difficile Toxins TcdA and TcdB
por: Papatheodorou, Panagiotis, et al.
Publicado: (2021)

Human α-Defensin-5 Efficiently Neutralizes Clostridioides difficile Toxins TcdA, TcdB, and CDT
por: Korbmacher, Michael, et al.
Publicado: (2020)

Human α-Defensin-6 Neutralizes Clostridioides difficile Toxins TcdA and TcdB by Direct Binding
por: Barthold, Lara, et al.
Publicado: (2022)

Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile
por: Hartley-Tassell, Lauren E., et al.
Publicado: (2019)

CdtR Regulates TcdA and TcdB Production in Clostridium difficile
por: Lyon, Shelley A., et al.
Publicado: (2016)

Neutralising Effects of Different Antibodies on Clostridioides difficile Toxins TcdA and TcdB in a Translational Approach
por: Csukovich, Georg, et al.
Publicado: (2023)

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues
por: Paparella, Ashleigh S., et al.
Publicado: (2021)

Development and characterization of phage display-derived anti-toxin antibodies neutralizing TcdA and TcdB of Clostridioides difficile
por: Raeisi, Hamideh, et al.
Publicado: (2023)

Ribotype Classification of Clostridioides difficile Isolates Is Not Predictive of the Amino Acid Sequence Diversity of the Toxin Virulence Factors TcdA and TcdB
por: Li, Zhenghui, et al.
Publicado: (2020)

A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile
por: Zhang, Bao-Zhong, et al.
Publicado: (2016)

A Colonic Organoid Model Challenged with the Large Toxins of Clostridioides difficile TcdA and TcdB Exhibit Deregulated Tight Junction Proteins
por: Schneemann, Martina, et al.
Publicado: (2023)

Association of tcdA+/tcdB+ Clostridium difficile Genotype with Emergence of Multidrug-Resistant Strains Conferring Metronidazole Resistant Phenotype
por: Shayganmehr, Farahnaz-Sadat, et al.
Publicado: (2015)

Study of the frequency of Clostridium difficile tcdA, tcdB, cdtA and cdtB genes in feces of Calves in south west of Iran
por: Doosti, Abbas, et al.
Publicado: (2014)

Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections
por: Carter, Glen P., et al.
Publicado: (2015)

Nanobodies against C. difficile TcdA and TcdB reveal unexpected neutralizing epitopes and provide a toolkit for toxin quantitation in vivo
por: Kordus, Shannon L., et al.
Publicado: (2023)

Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB
por: Ruhe, Frederike, et al.
Publicado: (2017)

Putative Conjugative Plasmids with tcdB and cdtAB Genes in Clostridioides difficile
por: Ramírez-Vargas, Gabriel, et al.
Publicado: (2020)

TcdB of Clostridioides difficile Mediates RAS-Dependent Necrosis in Epithelial Cells
por: Stieglitz, Florian, et al.
Publicado: (2022)

Amino Acid Differences in the 1753-to-1851 Region of TcdB Influence Variations in TcdB1 and TcdB2 Cell Entry
por: Hunt, Jonathan J., et al.
Publicado: (2017)

Development of Neutralizing and Non-neutralizing Antibodies Targeting Known and Novel Epitopes of TcdB of Clostridioides difficile
por: Fühner, Viola, et al.
Publicado: (2018)

Novel Biomarkers, Including tcdB PCR Cycle Threshold, for Predicting Recurrent Clostridioides difficile Infection
por: Madden, Gregory R., et al.
Publicado: (2023)

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality
por: Paparella, Ashleigh S., et al.
Publicado: (2023)

Variations in TcdB Activity and the Hypervirulence of Emerging Strains of Clostridium difficile
por: Lanis, Jordi M., et al.
Publicado: (2010)

The Role of TcdB and TccC Subunits in Secretion of the Photorhabdus Tcd Toxin Complex
por: Yang, Guowei, et al.
Publicado: (2013)

Clinical and microbiologic characteristics of tcdA-negative variant clostridium difficile infections
por: Kim, Jieun, et al.
Publicado: (2012)

Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
por: Chen, Peng, et al.
Publicado: (2021)

Esculin hydrolysis negative and TcdA‐only producing strains of Clostridium (Clostridioides) difficile from the environment in Western Australia
por: Shivaperumal, Nirajmohan, et al.
Publicado: (2022)

Intrinsic Toxin-Derived Peptides Destabilize and Inactivate Clostridium difficile TcdB
por: Larabee, Jason L., et al.
Publicado: (2017)

Novel Clostridium difficile Anti-Toxin (TcdA and TcdB) Humanized Monoclonal Antibodies Demonstrate In Vitro Neutralization across a Broad Spectrum of Clinical Strains and In Vivo Potency in a Hamster Spore Challenge Model
por: Qiu, Hongyu, et al.
Publicado: (2016)

Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S(N)i Mechanism and Ion Pair Transition State
por: Paparella, Ashleigh S., et al.
Publicado: (2022)

Nectin-3 and shed forms of CSPG4 can serve as epithelial cell receptors for Clostridioides difficile TcdB
por: Childress, Kevin O., et al.
Publicado: (2023)

The Antibiotic Bacitracin Protects Human Intestinal Epithelial Cells and Stem Cell-Derived Intestinal Organoids from Clostridium difficile Toxin TcdB
por: Zhu, Ziyu, et al.
Publicado: (2019)

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB
por: Li, Yingxue, et al.
Publicado: (2022)

Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities
por: Quesada-Gómez, Carlos, et al.
Publicado: (2016)

Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
por: Henkel, Daniel, et al.
Publicado: (2020)

Indeterminate tcdB using a Clostridium difficile PCR assay: a retrospective cohort study
por: Leis, Jerome A, et al.
Publicado: (2013)

Designed Ankyrin Repeat Protein (DARPin) Neutralizers of TcdB from Clostridium difficile Ribotype 027
por: Peng, Zeyu, et al.
Publicado: (2019)

Intestine epithelial cell-derived extracellular vesicles alleviate inflammation induced by Clostridioides difficile TcdB through the activity of TGF-β1
por: Wan, Shuangshuang, et al.
Publicado: (2022)

The TcdE holin drives toxin secretion and virulence in Clostridioides difficile
por: DiBenedetto, NV, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_6rg5ap6aqc6jkb5f6bpu3fl6ls