Characterization of N-Terminal Asparagine Deamidation and Clipping of a Monoclonal Antibody

This study presents a novel degradation pathway of a human immunoglobulin G (IgG) molecule featuring a light chain N-terminal asparagine. We thoroughly characterize this pathway and investigate its charge profiles using cation exchange chromatography (CEX) and capillary isoelectric focusing (cIEF)....

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Detalles Bibliográficos
Autores principales: Zhen, Jing, Lee, Jennifer, Wang, Yueyang, McLaughlin, Lena, Yang, Fei, Li, Zhengjian, Wang, Jihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525203/
https://www.ncbi.nlm.nih.gov/pubmed/37753973
http://dx.doi.org/10.3390/antib12030059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525203/
https://www.ncbi.nlm.nih.gov/pubmed/37753973
http://dx.doi.org/10.3390/antib12030059

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