Development and Validation of a High-Performance Liquid Chromatography with Tandem Mass Spectrometry (HPLC-MS/MS) Method for Quantification of Major Molnupiravir Metabolite (β-D-N4-hydroxycytidine) in Human Plasma

Molnupiravir is an antiviral drug against viral RNA polymerase activity approved by the FDA for the treatment of COVID-19, which is metabolized to β-D-N4-hydroxycytidine (NHC) in human blood plasma. A novel method was developed and validated for quantifying NHC in human plasma within the analytical...

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Detalles Bibliográficos
Autores principales: Komarov, Timofey, Karnakova, Polina, Archakova, Olga, Shchelgacheva, Dana, Bagaeva, Natalia, Popova, Mariia, Karpova, Polina, Zaslavskaya, Kira, Bely, Petr, Shohin, Igor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525314/
https://www.ncbi.nlm.nih.gov/pubmed/37760797
http://dx.doi.org/10.3390/biomedicines11092356

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525314/
https://www.ncbi.nlm.nih.gov/pubmed/37760797
http://dx.doi.org/10.3390/biomedicines11092356

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