Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation

The NRF2 transcription factor is a master regulator of the cellular oxidant/electrophile response and a drug target for the prevention/treatment of chronic diseases. A major mechanism of NRF2 activation is its escape from rapid degradation, and newly synthesized NRF2 induces cytoprotective protein e...

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Detalles Bibliográficos
Autores principales: Pensabene, Kaitlin M., LaMorte, Joseph, Allender, Amanda E., Wehr, Janessa, Kaur, Prabhjot, Savage, Matthew, Eggler, Aimee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525356/
https://www.ncbi.nlm.nih.gov/pubmed/37760038
http://dx.doi.org/10.3390/antiox12091735

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525356/
https://www.ncbi.nlm.nih.gov/pubmed/37760038
http://dx.doi.org/10.3390/antiox12091735

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