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Acute Oxidative Stress Can Paradoxically Suppress Human NRF2 Protein Synthesis by Inhibiting Global Protein Translation
The NRF2 transcription factor is a master regulator of the cellular oxidant/electrophile response and a drug target for the prevention/treatment of chronic diseases. A major mechanism of NRF2 activation is its escape from rapid degradation, and newly synthesized NRF2 induces cytoprotective protein e...
Autores principales: | Pensabene, Kaitlin M., LaMorte, Joseph, Allender, Amanda E., Wehr, Janessa, Kaur, Prabhjot, Savage, Matthew, Eggler, Aimee L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525356/ https://www.ncbi.nlm.nih.gov/pubmed/37760038 http://dx.doi.org/10.3390/antiox12091735 |
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