A Story of Kinases and Adaptors: The Role of Lck, ZAP-70 and LAT in Switch Panel Governing T-Cell Development and Activation

SIMPLE SUMMARY: Tyrosine phosphorylation is the first biochemical event that occurs after TCR engagement, which is crucial for T-cell development, activation and differentiation. Early TCR signals include phosphorylation events in which the tyrosine kinases Lck and ZAP70 are involved. The sequential...

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Detalles Bibliográficos
Autores principales: Fernández-Aguilar, Luis M., Vico-Barranco, Inmaculada, Arbulo-Echevarria, Mikel M., Aguado, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525366/
https://www.ncbi.nlm.nih.gov/pubmed/37759563
http://dx.doi.org/10.3390/biology12091163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525366/
https://www.ncbi.nlm.nih.gov/pubmed/37759563
http://dx.doi.org/10.3390/biology12091163

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