NRF2 Deficiency Attenuates Diabetic Kidney Disease in Db/Db Mice via Down-Regulation of Angiotensinogen, SGLT2, CD36, and FABP4 Expression and Lipid Accumulation in Renal Proximal Tubular Cells

The role(s) of nuclear factor erythroid 2-related factor 2 (NRF2) in diabetic kidney disease (DKD) is/are controversial. We hypothesized that Nrf2 deficiency in type 2 diabetes (T2D) db/db mice (db/dbNrf2 knockout (KO)) attenuates DKD progression through the down-regulation of angiotensinogen (AGT),...

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Detalles Bibliográficos
Autores principales: Su, Ke, Zhao, Shui-Ling, Yang, Wen-Xia, Lo, Chao-Sheng, Chenier, Isabelle, Liao, Min-Chun, Pang, Yu-Chao, Peng, Jun-Zheng, Miyata, Kana N., Cailhier, Jean-Francois, Ethier, Jean, Lattouf, Jean-Baptiste, Filep, Janos G., Ingelfinger, Julie R., Zhang, Shao-Ling, Chan, John S. D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525648/
https://www.ncbi.nlm.nih.gov/pubmed/37760019
http://dx.doi.org/10.3390/antiox12091715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525648/
https://www.ncbi.nlm.nih.gov/pubmed/37760019
http://dx.doi.org/10.3390/antiox12091715

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