Pharmacologic Ascorbate and DNMT Inhibitors Increase DUOX Expression and Peroxide-Mediated Toxicity in Pancreatic Cancer

Recent studies have demonstrated an important role for vitamin C in the epigenetic regulation of cancer-related genes via DNA demethylation by the ten-eleven translocation (TET) methylcytosine dioxygenase enzymes. DNA methyltransferase (DNMT) reverses this, increasing DNA methylation and decreasing...

Descripción completa

Detalles Bibliográficos
Autores principales: Steers, Garett J., O’Leary, Brianne R., Du, Juan, Wagner, Brett A., Carroll, Rory S., Domann, Frederick E., Goswami, Prabhat C., Buettner, Garry R., Cullen, Joseph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525653/
https://www.ncbi.nlm.nih.gov/pubmed/37759986
http://dx.doi.org/10.3390/antiox12091683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525653/
https://www.ncbi.nlm.nih.gov/pubmed/37759986
http://dx.doi.org/10.3390/antiox12091683

Ejemplares similares