Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse. Fibrate drugs, activating peroxisome proliferator-activated receptor alpha (PPA...

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Detalles Bibliográficos
Autores principales: Ibáñez, Cristina, Acuña, Tirso, Quintanilla, María Elena, Pérez-Reytor, Diliana, Morales, Paola, Karahanian, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525752/
https://www.ncbi.nlm.nih.gov/pubmed/37760061
http://dx.doi.org/10.3390/antiox12091758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525752/
https://www.ncbi.nlm.nih.gov/pubmed/37760061
http://dx.doi.org/10.3390/antiox12091758

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