Selective Inhibition of Cardiac Late Na(+) Current Is Based on Fast Offset Kinetics of the Inhibitor

The present study was designed to test the hypothesis that the selectivity of blocking the late Na(+) current (I(NaL)) over the peak Na(+) current (I(NaP)) is related to the fast offset kinetics of the Na(+) channel inhibitor. Therefore, the effects of 1 µM GS967 (I(NaL) inhibitor), 20 µM mexiletine...

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Detalles Bibliográficos
Autores principales: Naveed, Muhammad, Mohammed, Aiman Saleh A., Topal, Leila, Kovács, Zsigmond Máté, Dienes, Csaba, Ovári, József, Szentandrássy, Norbert, Magyar, János, Bányász, Tamás, Prorok, János, Jost, Norbert, Virág, László, Baczkó, István, Varró, András, Nánási, Péter P., Horváth, Balázs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525890/
https://www.ncbi.nlm.nih.gov/pubmed/37760824
http://dx.doi.org/10.3390/biomedicines11092383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10525890/
https://www.ncbi.nlm.nih.gov/pubmed/37760824
http://dx.doi.org/10.3390/biomedicines11092383

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