Cargando…

Persistent Hypoxia with Intermittent Aggravation Causes Imbalance in Smad3/Myocardin-Related Transcription Factor Signaling with Consequent Endothelial Senescence and Pulmonary Arterial Remodeling

Loss of Smad3 and the consequent activation of myocardin-related transcription factor (MRTF) are associated with vascular pathologies. This study aimed to examine the impact of persistent hypoxia with intermittent aggravation (PI hypoxia) on cellular senescence and pulmonary arterial remodeling medi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Jiaxin, Singh, Prachi, Li, Jingrui, Zhang, Jing, Li, Fei, Zhang, Hehe, Xie, Jiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526072/ https://www.ncbi.nlm.nih.gov/pubmed/37760802 http://dx.doi.org/10.3390/biomedicines11092351

Ejemplares similares

Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes
por: Polonis, Katarzyna, et al.
Publicado: (2020)

Myocardin in biology and disease
por: Miano, Joseph M
Publicado: (2015)

In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors
por: Mikhailov, Alexander T., et al.
Publicado: (2012)

Potential Role of mRNAs and LncRNAs in Chronic Intermittent Hypoxia Exposure-Aggravated Atherosclerosis
por: Zhang, Jing, et al.
Publicado: (2020)

Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling
por: Wang, Jun, et al.
Publicado: (2022)

The Potential Effects of Aliskiren on Atrial Remodeling Induced by Chronic Intermittent Hypoxia in Rats
por: Miao, Shuai, et al.
Publicado: (2020)

Angiotensin II and the ERK pathway mediate the induction of myocardin by hypoxia in cultured rat neonatal cardiomyocytes
por: Chiu, Chiung-Zuan, et al.
Publicado: (2010)

Intermittent Hypoxia Can Aggravate Motor Neuronal Loss and Cognitive Dysfunction in ALS Mice
por: Kim, Sung-Min, et al.
Publicado: (2013)

β-Catenin and Smad3 regulate the activity and stability of myocardin-related transcription factor during epithelial–myofibroblast transition
por: Charbonney, Emmanuel, et al.
Publicado: (2011)

Andrographolide Promotes Interaction Between Endothelin-Dependent EDNRA/EDNRB and Myocardin-SRF to Regulate Pathological Vascular Remodeling
por: Hu, Wangming, et al.
Publicado: (2022)

Myocardin and Stat3 act synergistically to inhibit cardiomyocyte apoptosis
por: Xiang, Yuan, et al.
Publicado: (2017)

Myocardin Reverses Hypoxia-Inducible Factor-1α Mediated Phenotypic Modulation of Corpus Cavernosum Smooth Muscle Cells in Hypoxia Induced by Cobalt Chloride
por: Zhou, Xiongcai, et al.
Publicado: (2023)

Myocardin Family Members Drive Formation of Caveolae
por: Krawczyk, Katarzyna K., et al.
Publicado: (2015)

Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
por: Morita, Tsuyoshi, et al.
Publicado: (2007)

Intermittent hypoxia causes NOX2-dependent remodeling of atrial connexins
por: Gemel, Joanna, et al.
Publicado: (2017)

YY1 directly interacts with myocardin to repress the triad myocardin/SRF/CArG box-mediated smooth muscle gene transcription during smooth muscle phenotypic modulation
por: Zheng, Jian-Pu, et al.
Publicado: (2020)

Salidroside Ameliorated Intermittent Hypoxia-Aggravated Endothelial Barrier Disruption and Atherosclerosis via the cAMP/PKA/RhoA Signaling Pathway
por: Li, Linyi, et al.
Publicado: (2021)

Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia
por: Huang, Jing, et al.
Publicado: (2021)

Intermittent Hypoxia in Childhood: The Harmful Consequences Versus Potential Benefits of Therapeutic Uses
por: Serebrovskaya, Tatiana V., et al.
Publicado: (2015)

Synergistic Activation of Cardiac Genes by Myocardin and Tbx5
por: Wang, Chunbo, et al.
Publicado: (2011)

Myocardin ablation in a cardiac-renal rat model
por: Mittal, Anupam, et al.
Publicado: (2019)

Retracted: Ameliorative Impact of Liraglutide on Chronic Intermittent Hypoxia-Induced Atrial Remodeling
por: Immunology Research, Journal of
Publicado: (2023)

Autophagy-Associated Atrophy and Metabolic Remodeling of the Mouse Diaphragm after Short-Term Intermittent Hypoxia
por: Giordano, Christian, et al.
Publicado: (2015)

Regulation of the Muscarinic M(3) Receptor by Myocardin-Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

Intermittent hypoxia regulates vasoactive molecules and alters insulin-signaling in vascular endothelial cells
por: Sharma, Pragya, et al.
Publicado: (2018)

Depletion of SENP1-mediated PPARγ SUMOylation exaggerates intermittent hypoxia-induced cognitive decline by aggravating microglia-mediated neuroinflammation
por: Wang, Hongwei, et al.
Publicado: (2021)

Intermittent hypoxia mimicking obstructive sleep apnea aggravates early brain injury following ICH via neuroinflammation and apoptosis
por: Fei, Wenjing, et al.
Publicado: (2021)

Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2018)

Endothelial senescence mediates hypoxia-induced vascular remodeling by modulating PDGFB expression
por: Kyi, Priscilla, et al.
Publicado: (2022)

Reduced circulating growth hormone and insulin-like growth factor-1 and delayed growth of premature rats are aggravated by longer daily duration of chronic intermittent hypoxia exposure
por: Zhang, Chi, et al.
Publicado: (2023)

Hypobaric Intermittent Hypoxia Attenuates Hypoxia-induced Depressor Response
por: Cui, Fang, et al.
Publicado: (2012)

Chemokine/Interleukin Imbalance Aggravates the Pathology of Respiratory Syncytial Virus Infection
por: Mori, Kentaro, et al.
Publicado: (2022)

Aggravated Gut Microbiota and Metabolomic Imbalances Are Associated with Hypertension Patients Comorbid with Atrial Fibrillation
por: Fang, Chen, et al.
Publicado: (2022)

Cell Type Dependent Suppression of Inflammatory Mediators by Myocardin Related Transcription Factors
por: Liu, Li, et al.
Publicado: (2021)

Arp5 is a key regulator of myocardin in smooth muscle cells
por: Morita, Tsuyoshi, et al.
Publicado: (2014)

Loss-of-function variants in myocardin cause congenital megabladder in humans and mice
por: Houweling, Arjan C., et al.
Publicado: (2019)

Correction to: Myocardin regulates mitochondrial calcium homeostasis and prevents permeability transition
por: Mughal, Wajihah, et al.
Publicado: (2019)

Systemic lupus erythematosus aggravates atherosclerosis by promoting IgG deposition and inflammatory cell imbalance
por: Liu, T, et al.
Publicado: (2020)

Correction: Hypobaric Intermittent Hypoxia Attenuates Hypoxia-induced Depressor Response
por: Cui, Fang, et al.
Publicado: (2013)

High glucose downregulates myocardin expression in rat glomerular mesangial cells via the ERK signaling pathway
por: Li, Ming, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bplge74etsls20ouufti84ov8i