Phylogenetic Analysis Guides Transporter Protein Deorphanization: A Case Study of the SLC25 Family of Mitochondrial Metabolite Transporters

Homology search and phylogenetic analysis have commonly been used to annotate gene function, although they are prone to error. We hypothesize that the power of homology search in functional annotation depends on the coupling of sequence variation to functional diversification, and we herein focus on...

Descripción completa

Detalles Bibliográficos
Autores principales: Byrne, Katie L., Szeligowski, Richard V., Shen, Hongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526428/
https://www.ncbi.nlm.nih.gov/pubmed/37759714
http://dx.doi.org/10.3390/biom13091314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526428/
https://www.ncbi.nlm.nih.gov/pubmed/37759714
http://dx.doi.org/10.3390/biom13091314

Ejemplares similares