Targeted elimination of senescent cells by engineered extracellular vesicles attenuates atherosclerosis in ApoE(-/-) mice with minimal side effects

Senescent cells in plaques emerge as a detrimental factor for atherosclerosis (AS), for which targeted senolysis might be a promising therapeutic strategy. The development of safe and efficient senolytics for senescent cell eradication by targeted delivery is greatly needed. Methods: Pro-apoptotic i...

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Detalles Bibliográficos
Autores principales: Zhang, Liang, Wang, Chen, Hu, Wei, Bu, Te, Sun, Wenqi, Zhou, Tian, Qiu, Shuo, Wei, Mengying, Xing, Helin, Li, Zhelong, Yang, Guodong, Yuan, Lijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526664/
https://www.ncbi.nlm.nih.gov/pubmed/37771781
http://dx.doi.org/10.7150/thno.87484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526664/
https://www.ncbi.nlm.nih.gov/pubmed/37771781
http://dx.doi.org/10.7150/thno.87484

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