Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE(-/-)mice

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD) as well as stroke. Endothelial metabolic disorder has been found to be activated and then promote endothelial cells (ECs) injury, which is regarded to initiate AS progression. N-acetylneuraminic acid (Neu5Ac),...

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Detalles Bibliográficos
Autores principales: Xiang, Peng, Chen, Qingqiu, Chen, Le, Lei, Jin, Yuan, Zhiyi, Hu, Hui, Lu, Yining, Wang, Xianmin, Wang, Tingting, Yu, Ruihong, Zhang, Wanping, Zhang, Jun, Yu, Chao, Ma, Limei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526676/
https://www.ncbi.nlm.nih.gov/pubmed/37771765
http://dx.doi.org/10.7150/thno.87968

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526676/
https://www.ncbi.nlm.nih.gov/pubmed/37771765
http://dx.doi.org/10.7150/thno.87968

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