Exploring the Potential of Sulfur Moieties in Compounds Inhibiting Steroidogenesis

This study reports on the synthesis and evaluation of novel compounds replacing the nitrogen-containing heterocyclic ring on the chemical backbone structure of cytochrome P450 17α-hydroxylase/12,20-lyase (CYP17A1) inhibitors with a phenyl bearing a sulfur-based substituent. Initial screening reveale...

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Detalles Bibliográficos
Autores principales: Wróbel, Tomasz M., Sharma, Katyayani, Mannella, Iole, Oliaro-Bosso, Simonetta, Nieckarz, Patrycja, Du Toit, Therina, Voegel, Clarissa Daniela, Rojas Velazquez, Maria Natalia, Yakubu, Jibira, Matveeva, Anna, Therkelsen, Søren, Jørgensen, Flemming Steen, Pandey, Amit V., Pippione, Agnese C., Lolli, Marco L., Boschi, Donatella, Björkling, Fredrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526780/
https://www.ncbi.nlm.nih.gov/pubmed/37759751
http://dx.doi.org/10.3390/biom13091349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10526780/
https://www.ncbi.nlm.nih.gov/pubmed/37759751
http://dx.doi.org/10.3390/biom13091349

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