Cargando…

X-ray Crystallographic Study of Preferred Spacing by the NF-κB p50 Homodimer on κB DNA

Though originally characterized as an inactive or transcriptionally repressive factor, the NF-κB p50 homodimer has become appreciated as a physiologically relevant driver of specific target gene expression. By virtue of its low affinity for cytoplasmic IκB protein inhibitors, p50 accumulates in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Norman, Mealka, Matthew, Mitchel, Shane, Milani, Christy, Acuña, Lisa M., Rogers, Eric, Lahana, Ashlee N., Huxford, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527052/ https://www.ncbi.nlm.nih.gov/pubmed/37759710 http://dx.doi.org/10.3390/biom13091310

Ejemplares similares

Assaying Homodimers of NF-κB in Live Single Cells
por: Martin, Erik W., et al.
Publicado: (2019)

IκBβ enhances the generation of the low-affinity NFκB/RelA homodimer
por: Tsui, Rachel, et al.
Publicado: (2015)

Atypical IκB Bcl3 enhances the generation of the NF-κB p52 homodimer
por: Pan, Wenfei, et al.
Publicado: (2022)

The NF-κB p65 and p50 homodimer cooperate with IRF8 to activate iNOS transcription
por: Simon, Priscilla S., et al.
Publicado: (2015)

Structural and dynamic studies of DNA recognition by NF-κB p50 RHR homodimer using methyl NMR spectroscopy
por: Singh, Amrinder, et al.
Publicado: (2022)

Polydnavirus Ank Proteins Bind NF-κB Homodimers and Inhibit Processing of Relish
por: Bitra, Kavita, et al.
Publicado: (2012)

Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation
por: Pan, Wenfei, et al.
Publicado: (2023)

The human parasite Leishmania amazonensis downregulates iNOS expression via NF-κB p50/p50 homodimer: role of the PI3K/Akt pathway
por: Calegari-Silva, Teresa C., et al.
Publicado: (2015)

The levels of NF-κB p50 and NF-κB p65 play a role in thyroid carcinoma malignancy in vivo
por: Le, Fei, et al.
Publicado: (2018)

The regulation of sequence specific NF-κB DNA binding and transcription by IKKβ phosphorylation of NF-κB p50 at serine 80
por: Smith, Emma L, et al.
Publicado: (2019)

Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation
por: Nakamura-Yanagidaira, Tomoko, et al.
Publicado: (2011)

Insect Neuropeptide Bursicon Homodimers Induce Innate Immune and Stress Genes during Molting by Activating the NF-κB Transcription Factor Relish
por: An, Shiheng, et al.
Publicado: (2012)

NF-κB and Disease
por: Poma, Paola
Publicado: (2020)

NF-κB and the Immunoglobulin κ Gene Enhancer
por: Sen, Ranjan
Publicado: (2004)

NF-κB Members Left Home: NF-κB-Independent Roles in Cancer
por: Colomer, Carlota, et al.
Publicado: (2017)

Expression of COX-2, NF-κB-p65, NF-κB-p50 and IKKα in malignant and adjacent normal human colorectal tissue
por: Charalambous, M P, et al.
Publicado: (2009)

Non-canonical NFκB mutations reinforce pro-survival TNF response in multiple myeloma through an autoregulatory RelB:p50 NFκB pathway
por: Roy, P, et al.
Publicado: (2017)

The effects of pentoxifylline administration on NFΚB P50 transcription factor expression
por: Shamsara, Jamal, et al.
Publicado: (2012)

In Silico and In Vitro Screening of 50 Curcumin Compounds as EGFR and NF-κB Inhibitors
por: Saeed, Mohamed E. M., et al.
Publicado: (2022)

Rad50 promotes ovarian cancer progression through NF‐κB activation
por: Li, Yinuo, et al.
Publicado: (2021)

Analysis of variation in NF-κB genes and expression levels of NF-κB-regulated molecules
por: Liu-Mares, Wen, et al.
Publicado: (2007)

NF-κB fingerprinting reveals heterogeneous NF-κB composition in diffuse large B-cell lymphoma
por: Jayawant, Eleanor, et al.
Publicado: (2023)

DNA damage-induced cytotoxicity is mediated by the cooperative interaction of phospho-NF-κB p50 and a single nucleotide in the κB-site
por: Crawley, Clayton D., et al.
Publicado: (2013)

Keeping NF-κB in check
por: Williams, Ruth
Publicado: (2006)

At the crossroads of SUMO and NF-κB
por: Kracklauer, Martin P, et al.
Publicado: (2003)

Slow but steady for NF-κB
por: Leslie, Mitch
Publicado: (2012)

NF-κB in premature aging
por: Osorio, Fernando G., et al.
Publicado: (2012)

Hypoxia Induced NF-κB
por: D’Ignazio, Laura, et al.
Publicado: (2016)

NF-κB signaling in inflammation
por: Liu, Ting, et al.
Publicado: (2017)

Noncanonical NF-κB in Cancer
por: Tegowski, Matthew, et al.
Publicado: (2018)

NFκB and Kidney Injury
por: Song, Ning, et al.
Publicado: (2019)

NF-κB in Hematological Malignancies
por: Imbert, Véronique, et al.
Publicado: (2017)

NF-κB Signalling in Glioblastoma
por: Soubannier, Vincent, et al.
Publicado: (2017)

NF-κB Mutations in Germinal Center B-Cell Lymphomas: Relation to NF-κB Function in Normal B Cells
por: Pasqualucci, Laura, et al.
Publicado: (2022)

Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
por: Shukla, Sanjeev, et al.
Publicado: (2015)

To NFκB or not to NFκB: The Dilemma on How to Inhibit a Cancer Cell Fate Regulator
por: Sorriento, Daniela, et al.
Publicado: (2012)

Atypical IκB proteins – nuclear modulators of NF-κB signaling
por: Schuster, Marc, et al.
Publicado: (2013)

Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis
por: Zhou, Yifan, et al.
Publicado: (2020)

BAG-1 interacts with the p50-p50 homodimeric NF-κB complex: implications for colorectal carcinogenesis
por: Southern, Samantha L., et al.
Publicado: (2011)

Comparison of backbone dynamics of the p50 dimerization domain of NFκB in the homodimeric transcription factor NFκB1 and in its heterodimeric complex with RelA (p65)
por: Kohl, Bastian, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hro7qtpu19e4ageir7eqt32e81