The Potential Mechanisms behind Loperamide-Induced Cardiac Arrhythmias Associated with Human Abuse and Extreme Overdose

Loperamide has been a safe and effective treatment for diarrhea for many years. However, many cases of cardiotoxicity with intentional abuse of loperamide ingestion have recently been reported. We evaluated loperamide in in vitro and in vivo cardiac safety models to understand the mechanisms for thi...

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Detalles Bibliográficos
Autores principales: Lu, Hua Rong, Damiano, Bruce P., Kreir, Mohamed, Rohrbacher, Jutta, van der Linde, Henk, Saidov, Tamerlan, Teisman, Ard, Gallacher, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527387/
https://www.ncbi.nlm.nih.gov/pubmed/37759755
http://dx.doi.org/10.3390/biom13091355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527387/
https://www.ncbi.nlm.nih.gov/pubmed/37759755
http://dx.doi.org/10.3390/biom13091355

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