Free Bilirubin Induces Neuro-Inflammation in an Induced Pluripotent Stem Cell-Derived Cortical Organoid Model of Crigler-Najjar Syndrome

Bilirubin-induced neurological damage (BIND), which might progress to kernicterus, occurs as a consequence of defects in the bilirubin conjugation machinery, thus enabling albumin-unbound free bilirubin (BF) to cross the blood–brain barrier and accumulate within. A defect in the UGT1A1 enzyme-encodi...

Descripción completa

Detalles Bibliográficos
Autores principales: Pranty, Abida Islam, Wruck, Wasco, Adjaye, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527749/
https://www.ncbi.nlm.nih.gov/pubmed/37759499
http://dx.doi.org/10.3390/cells12182277

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527749/
https://www.ncbi.nlm.nih.gov/pubmed/37759499
http://dx.doi.org/10.3390/cells12182277

Ejemplares similares