TGFβ−2 haploinsufficiency causes early death in mice with Marfan syndrome

To assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome (MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the gene defective in MFS) hypomorphic mutation and a TGF-β1, 2, or 3 heterozygous null mutation. The loss of TGF-β2, and only...

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Detalles Bibliográficos
Autores principales: Sachan, Nalani, Phoon, Colin K.L., Zilberberg, Lior, Kugler, Matthias C., Ene, Taylor, Mintz, Shana B., Murtada, Sae-Il, Weiss, Dar, Fishman, Glenn I., Humphrey, Jay D., Rifkin, Daniel B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527763/
https://www.ncbi.nlm.nih.gov/pubmed/37217119
http://dx.doi.org/10.1016/j.matbio.2023.05.004

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10527763/
https://www.ncbi.nlm.nih.gov/pubmed/37217119
http://dx.doi.org/10.1016/j.matbio.2023.05.004

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