Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions

C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding proteins including stress granule (SG) proteins. However, little i...

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Detalles Bibliográficos
Autores principales: Park, Jinyoung, Wu, Yanwei, Shao, Wei, Gendron, Tania F., van der Spek, Sophie J.F., Sultanakhmetov, Grigorii, Basu, Avik, Otero, Paula Castellanos, Jones, Caroline J., Jansen-West, Karen, Daughrity, Lillian M., Phanse, Sadhna, del Rosso, Giulia, Tong, Jimei, Castanedes-Casey, Monica, Jiang, Lulu, Libera, Jenna, Oskarsson, Björn, Dickson, Dennis W., Sanders, David W., Brangwynne, Clifford P., Emili, Andrew, Wolozin, Benjamin, Petrucelli, Leonard, Zhang, Yong-Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528326/
https://www.ncbi.nlm.nih.gov/pubmed/37471224
http://dx.doi.org/10.1016/j.celrep.2023.112822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528326/
https://www.ncbi.nlm.nih.gov/pubmed/37471224
http://dx.doi.org/10.1016/j.celrep.2023.112822

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