Cargando…
Poly(GR) interacts with key stress granule factors promoting its assembly into cytoplasmic inclusions
C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding proteins including stress granule (SG) proteins. However, little i...
Autores principales: | Park, Jinyoung, Wu, Yanwei, Shao, Wei, Gendron, Tania F., van der Spek, Sophie J.F., Sultanakhmetov, Grigorii, Basu, Avik, Otero, Paula Castellanos, Jones, Caroline J., Jansen-West, Karen, Daughrity, Lillian M., Phanse, Sadhna, del Rosso, Giulia, Tong, Jimei, Castanedes-Casey, Monica, Jiang, Lulu, Libera, Jenna, Oskarsson, Björn, Dickson, Dennis W., Sanders, David W., Brangwynne, Clifford P., Emili, Andrew, Wolozin, Benjamin, Petrucelli, Leonard, Zhang, Yong-Jie |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528326/ https://www.ncbi.nlm.nih.gov/pubmed/37471224 http://dx.doi.org/10.1016/j.celrep.2023.112822 |
Ejemplares similares
-
HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS
por: del Rosso, Giulia, et al.
Publicado: (2022) -
Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy
por: Chew, Jeannie, et al.
Publicado: (2019) -
Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model
por: Jansen-West, Karen, et al.
Publicado: (2022) -
Tau exhibits unique seeding properties in globular glial tauopathy
por: Chung, Dah-eun Chloe, et al.
Publicado: (2019) -
Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease
por: Sakae, Nobutaka, et al.
Publicado: (2018)