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Chemogenetic regulation of the TARP-lipid interaction mimics LTP and reversibly modifies behavior

Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, is believed to underlie memory formation. Hebbian, postsynaptically expressed LTP requires TARPγ–8 phosphorylation for synaptic insertion of AMPA receptors (AMPARs). However, it is unknown whether TARP-mediated AMPAR ins...

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Detalles Bibliográficos
Autores principales: Park, Joongkyu, Berthoux, Coralie, Hoyos-Ramirez, Erika, Shan, Lili, Morimoto-Tomita, Megumi, Wang, Yixiang, Castillo, Pablo E., Tomita, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528344/
https://www.ncbi.nlm.nih.gov/pubmed/37471228
http://dx.doi.org/10.1016/j.celrep.2023.112826