Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design

Broadly neutralizing antibodies (bNAbs) against HIV can reduce viral transmission in humans, but an effective therapeutic will require unusually high breadth and potency of neutralization. We employ the OSPREY computational protein design software to engineer variants of two apex-directed bNAbs, PGT...

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Detalles Bibliográficos
Autores principales: Holt, Graham T., Gorman, Jason, Wang, Siyu, Lowegard, Anna U., Zhang, Baoshan, Liu, Tracy, Lin, Bob C., Louder, Mark K., Frenkel, Marcel S., McKee, Krisha, O’Dell, Sijy, Rawi, Reda, Shen, Chen-Hsiang, Doria-Rose, Nicole A., Kwong, Peter D., Donald, Bruce R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528384/
https://www.ncbi.nlm.nih.gov/pubmed/37436900
http://dx.doi.org/10.1016/j.celrep.2023.112711

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528384/
https://www.ncbi.nlm.nih.gov/pubmed/37436900
http://dx.doi.org/10.1016/j.celrep.2023.112711

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