Cargando…

Choosing statins: a review to guide clinical practice

Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for r...

Descripción completa

Detalles Bibliográficos
Autores principales: Borges, Roberta de Pádua, Degobi, Nathália Abi Habib, Bertoluci, Marcello Casaccia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Endocrinologia e Metabologia 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528630/
https://www.ncbi.nlm.nih.gov/pubmed/33166435
http://dx.doi.org/10.20945/2359-3997000000306
_version_ 1785111291105378304
author Borges, Roberta de Pádua
Degobi, Nathália Abi Habib
Bertoluci, Marcello Casaccia
author_facet Borges, Roberta de Pádua
Degobi, Nathália Abi Habib
Bertoluci, Marcello Casaccia
author_sort Borges, Roberta de Pádua
collection PubMed
description Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios.
format Online
Article
Text
id pubmed-10528630
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Sociedade Brasileira de Endocrinologia e Metabologia
record_format MEDLINE/PubMed
spelling pubmed-105286302023-09-28 Choosing statins: a review to guide clinical practice Borges, Roberta de Pádua Degobi, Nathália Abi Habib Bertoluci, Marcello Casaccia Arch Endocrinol Metab Review Statins are among the most widely prescribed medicines in the world and have proved their value in reducing cardiovascular events and mortality. Many patients report adverse effects that lead to interruption of treatment. This review aims to individualize statin treatment, considering efficacy for reducing cardiovascular risk and safety, in the setting of specific diseases, to minimize the side effects and improve compliance. We gathered evidence that may help clinicians to choose specific statins in different clinical situations, such as the risk of new diabetes, chronic kidney disease, liver disease, human immunodeficiency virus infection, organ transplant, heart failure and elderly people. Efficacy of statins is well established in a large number of clinical conditions. Therefore, main objective is to revise statin in specific clinical settings, based on pharmacokinetics, safety, drug metabolism and interactions to provide the best choice in different clinical scenarios. Sociedade Brasileira de Endocrinologia e Metabologia 2020-11-09 /pmc/articles/PMC10528630/ /pubmed/33166435 http://dx.doi.org/10.20945/2359-3997000000306 Text en https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Borges, Roberta de Pádua
Degobi, Nathália Abi Habib
Bertoluci, Marcello Casaccia
Choosing statins: a review to guide clinical practice
title Choosing statins: a review to guide clinical practice
title_full Choosing statins: a review to guide clinical practice
title_fullStr Choosing statins: a review to guide clinical practice
title_full_unstemmed Choosing statins: a review to guide clinical practice
title_short Choosing statins: a review to guide clinical practice
title_sort choosing statins: a review to guide clinical practice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528630/
https://www.ncbi.nlm.nih.gov/pubmed/33166435
http://dx.doi.org/10.20945/2359-3997000000306
work_keys_str_mv AT borgesrobertadepadua choosingstatinsareviewtoguideclinicalpractice
AT degobinathaliaabihabib choosingstatinsareviewtoguideclinicalpractice
AT bertolucimarcellocasaccia choosingstatinsareviewtoguideclinicalpractice