FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress

Fatty acid synthase (FASN) maintains de novo lipogenesis (DNL) to support rapid growth in most proliferating cancer cells. Lipogenic acetyl-coenzyme A (CoA) is primarily produced from carbohydrates but can arise from glutamine-dependent reductive carboxylation. Here, we show that reductive carboxyla...

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Detalles Bibliográficos
Autores principales: Dai, Wenting, Wang, Zhichao, Wang, Guan, Wang, Qiong A., DeBerardinis, Ralph, Jiang, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528718/
https://www.ncbi.nlm.nih.gov/pubmed/37578864
http://dx.doi.org/10.1016/j.celrep.2023.112971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528718/
https://www.ncbi.nlm.nih.gov/pubmed/37578864
http://dx.doi.org/10.1016/j.celrep.2023.112971

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