mTOR inhibition reprograms cellular proteostasis by regulating eIF3D-mediated selective mRNA translation and promotes cell phenotype switching

Cells maintain and dynamically change their proteomes according to the environment and their needs. Mechanistic target of rapamycin (mTOR) is a key regulator of proteostasis, homeostasis of the proteome. Thus, dysregulation of mTOR leads to changes in proteostasis and the consequent progression of d...

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Detalles Bibliográficos
Autores principales: Shin, Sejeong, Han, Min-Joon, Jedrychowski, Mark P., Zhang, Ziyang, Shokat, Kevan M., Plas, David R., Dephoure, Noah, Yoon, Sang-Oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528759/
https://www.ncbi.nlm.nih.gov/pubmed/37494188
http://dx.doi.org/10.1016/j.celrep.2023.112868

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10528759/
https://www.ncbi.nlm.nih.gov/pubmed/37494188
http://dx.doi.org/10.1016/j.celrep.2023.112868

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