ATR protects ongoing and newly assembled DNA replication forks through distinct mechanisms

The ATR kinase safeguards genomic integrity during S phase, but how ATR protects DNA replication forks remains incompletely understood. Here, we combine four distinct assays to analyze ATR functions at ongoing and newly assembled replication forks upon replication inhibition by hydroxyurea. At ongoi...

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Detalles Bibliográficos
Autores principales: Leung, Wendy, Simoneau, Antoine, Saxena, Sneha, Jackson, Jessica, Patel, Parasvi S., Limbu, Mangsi, Vindigni, Alessandro, Zou, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529362/
https://www.ncbi.nlm.nih.gov/pubmed/37454295
http://dx.doi.org/10.1016/j.celrep.2023.112792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529362/
https://www.ncbi.nlm.nih.gov/pubmed/37454295
http://dx.doi.org/10.1016/j.celrep.2023.112792

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