HSP90 Inhibitor PU-H71 in Combination with BH3-Mimetics in the Treatment of Acute Myeloid Leukemia

Targeting the molecular chaperone HSP90 and the anti-apoptotic proteins MCL1 and BCL2 may be a promising novel approach in the treatment of acute myeloid leukemia (AML). The HSP90 inhibitor PU-H71, MCL1 inhibitor S63845, and BCL2 inhibitor venetoclax were assessed as single agents and in combination...

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Detalles Bibliográficos
Autores principales: Seipel, Katja, Kohler, Scarlett, Bacher, Ulrike, Pabst, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529370/
https://www.ncbi.nlm.nih.gov/pubmed/37754227
http://dx.doi.org/10.3390/cimb45090443

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529370/
https://www.ncbi.nlm.nih.gov/pubmed/37754227
http://dx.doi.org/10.3390/cimb45090443

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