Cargando…

Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

The bone marrow microenvironment (BME) drives drug resistance in acute lymphoblastic leukemia (ALL) through leukemic cell interactions with bone marrow (BM) niches, but the underlying mechanisms remain unclear. Here, we show that the interaction between ALL and mesenchymal stem cells (MSCs) through...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Chun Shik, Yoshihara, Hiroki, Gao, Qingsong, Qu, Chunxu, Iacobucci, Ilaria, Ghate, Pankaj S., Connelly, Jon P., Pruett-Miller, Shondra M., Wagner, Ben, Robinson, Camenzind G., Mishra, Ashutosh, Peng, Junmin, Yang, Lei, Rankovic, Zoran, Finkelstein, David, Luger, Selina, Litzow, Mark, Paietta, Elisabeth M., Hebbar, Nikhil, Velasquez, M. Paulina, Mullighan, Charles G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529385/ https://www.ncbi.nlm.nih.gov/pubmed/37453060 http://dx.doi.org/10.1016/j.celrep.2023.112804

Ejemplares similares

Acute lymphoblastic leukemia displays a distinct highly methylated genome
por: Hetzel, Sara, et al.
Publicado: (2022)

CRIS.py: A Versatile and High-throughput Analysis Program for CRISPR-based Genome Editing
por: Connelly, Jon P., et al.
Publicado: (2019)

A Look to Future Directions in Gene Therapy Research for Monogenic Diseases
por: Porteus, Matthew H, et al.
Publicado: (2006)

At three years, patients with acute lymphoblastic leukaemia are still at risk for relapse. Results of the international MRC UKALLXII/ECOG E2993 trial
por: Ganzel, Chezi, et al.
Publicado: (2020)

Short tandem repeat profiling via next-generation sequencing for cell line authentication
por: Chen, Yi-Hsien, et al.
Publicado: (2023)

CNS involvement in AML at diagnosis is rare and does not affect response or survival: data from 11 ECOG-ACRIN trials
por: Ganzel, Chezi, et al.
Publicado: (2021)

A Survey of Validation Strategies for CRISPR-Cas9 Editing
por: Sentmanat, Monica F., et al.
Publicado: (2018)

Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators
por: Nishiguchi, Gisele, et al.
Publicado: (2021)

CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk
por: Baer, Constance, et al.
Publicado: (2022)

A proteomics approach for the identification of cullin-9 (CUL9) related signaling pathways in induced pluripotent stem cell models
por: Ortolano, Natalya A., et al.
Publicado: (2021)

Inflammatory cell death, PANoptosis, screen identifies host factors in coronavirus innate immune response as therapeutic targets
por: Malireddi, R. K. Subbarao, et al.
Publicado: (2023)

Nuclease-mediated gene editing by homologous recombination of the human globin locus
por: Voit, Richard A., et al.
Publicado: (2014)

Therapeutic gene editing strategies using CRISPR-Cas9 for the β-hemoglobinopathies
por: Papizan, James B., et al.
Publicado: (2021)

Whole-genome CRISPR screen identifies RAVER1 as a key regulator of RIPK1-mediated inflammatory cell death, PANoptosis
por: Malireddi, R.K. Subbarao, et al.
Publicado: (2023)

Cytoneme delivery of Sonic Hedgehog from ligand-producing cells requires Myosin 10 and a Dispatched-BOC/CDON co-receptor complex
por: Hall, Eric T, et al.
Publicado: (2021)

A microalga, Euglena tuba induces apoptosis and suppresses metastasis in human lung and breast carcinoma cells through ROS-mediated regulation of MAPKs
por: Panja, Sourav, et al.
Publicado: (2016)

Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
por: Pruett-Miller, Shondra M., et al.
Publicado: (2009)

Heartwood extract of Acacia catechu induces apoptosis in human breast carcinoma by altering bax/bcl-2 ratio
por: Ghate, Nikhil Baban, et al.
Publicado: (2014)

Role of phenolics from Spondias pinnata bark in amelioration of iron overload induced hepatic damage in Swiss albino mice
por: Chaudhuri, Dipankar, et al.
Publicado: (2016)

SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation
por: Shen, Leyao, et al.
Publicado: (2022)

Positional cloning of quantitative trait nucleotides for blood pressure and cardiac QT-interval by targeted CRISPR/Cas9 editing of a novel long non-coding RNA
por: Cheng, Xi, et al.
Publicado: (2017)

Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections
por: Zheng, Min, et al.
Publicado: (2021)

An Antioxidant Extract of the Insectivorous Plant Drosera burmannii Vahl. Alleviates Iron-Induced Oxidative Stress and Hepatic Injury in Mice
por: Ghate, Nikhil Baban, et al.
Publicado: (2015)

Functional investigation of inherited noncoding genetic variation impacting the pharmacogenomics of childhood acute lymphoblastic leukemia treatment
por: Bhattarai, Kashi Raj, et al.
Publicado: (2023)

A Paraneoplastic Syndrome Characterized by Extremity Swelling with Associated Inflammatory Infiltrate Heralds Aggressive Transformation of Myelodysplastic Syndromes/Myeloproliferative Neoplasms to Acute Myeloid Leukemia: A Case Series
por: Mangan, James K., et al.
Publicado: (2012)

Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia
por: Iacobucci, Ilaria, et al.
Publicado: (2021)

Wild Edible Fruit of Prunus nepalensis Ser. (Steud), a Potential Source of Antioxidants, Ameliorates Iron Overload-Induced Hepatotoxicity and Liver Fibrosis in Mice
por: Chaudhuri, Dipankar, et al.
Publicado: (2015)

A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin
por: Lynch, John, et al.
Publicado: (2023)

Engineering Human Pluripotent Stem Cell Lines to Evade Xenogeneic Transplantation Barriers
por: Pizzato, Hannah A., et al.
Publicado: (2023)

Glutathione limits RUNX2 oxidation and degradation to regulate bone formation
por: Hu, Guoli, et al.
Publicado: (2023)

DIPG-34. IMMUNE SYNAPSE OPTIMIZED GRP78-SPECIFIC CAR T CELLS ELICIT AN IMPROVED ANTITUMOR RESPONSE AGAINST DIPGS
por: Ibanez, Jorge, et al.
Publicado: (2023)

Dose intensity for induction in acute myeloid leukemia: what, when, and for whom?
por: McCurdy, Shannon R., et al.
Publicado: (2021)

Ribonucleotide reductase subunit switching in hepatoblastoma drug response and relapse
por: Brown, Anthony, et al.
Publicado: (2023)

Schizophrenia-related microdeletion causes defective ciliary motility and brain ventricle enlargement via microRNA-dependent mechanisms in mice
por: Eom, Tae-Yeon, et al.
Publicado: (2020)

Silica nanoparticles induce endoplasmic reticulum stress response, oxidative stress and activate the mitogen-activated protein kinase (MAPK) signaling pathway
por: Christen, Verena, et al.
Publicado: (2014)

S115: CONSOLIDATION WITH BLINATUMOMAB IMPROVES OVERALL AND RELAPSE-FREE SURVIVAL IN PATIENTS WITH NEWLY DIAGNOSED B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA: IMPACT OF AGE AND MRD LEVEL IN ECOG-ACRIN E1910
por: Litzow, Mark, et al.
Publicado: (2023)

Glycoside rich fraction from Spondias pinnata bark ameliorate iron overload induced oxidative stress and hepatic damage in Swiss albino mice
por: Chaudhuri, Dipankar, et al.
Publicado: (2016)

Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification
por: Wilson, Kimberly A, et al.
Publicado: (2013)

Mutual antagonism between glucocorticoid and canonical Wnt signaling pathways in B-cell acute lymphoblastic leukemia
por: Bergeron, Brennan P., et al.
Publicado: (2023)

GRP78 Is a Targetable Receptor on Cancer and Stromal Cells
por: Araujo, Nathalia, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rbk14kajd9pltq5ui7iqvecnbm