Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification on biology

Rad24-RFC (replication factor C) loads the 9-1-1 checkpoint clamp onto the recessed 5′ ends by binding a 5′ DNA at an external surface site and threading the 3′ single-stranded DNA (ssDNA) into 9-1-1. We find here that Rad24-RFC loads 9-1-1 onto DNA gaps in preference to a recessed 5′ end, thus pres...

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Detalles Bibliográficos
Autores principales: Zheng, Fengwei, Georgescu, Roxana E., Yao, Nina Y., O’Donnell, Michael E., Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529453/
https://www.ncbi.nlm.nih.gov/pubmed/37392384
http://dx.doi.org/10.1016/j.celrep.2023.112694

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529453/
https://www.ncbi.nlm.nih.gov/pubmed/37392384
http://dx.doi.org/10.1016/j.celrep.2023.112694

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