Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers

The absence of germinal centers (GCs) in cartilaginous fishes lies at odds with data showing that nurse sharks can produce robust antigen-specific responses and affinity mature their B cell repertoires. To investigate this apparent incongruity, we performed RNA sequencing on single nuclei, allowing...

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Detalles Bibliográficos
Autores principales: Matz, Hanover, Taylor, Richard S., Redmond, Anthony K., Hill, Thomas M., Daniels, Rose Ruiz, Beltran, Mariana, Henderson, Neil C., Macqueen, Daniel J., Dooley, Helen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529500/
https://www.ncbi.nlm.nih.gov/pubmed/37342909
http://dx.doi.org/10.1016/j.celrep.2023.112664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529500/
https://www.ncbi.nlm.nih.gov/pubmed/37342909
http://dx.doi.org/10.1016/j.celrep.2023.112664

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