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Organized B cell sites in cartilaginous fishes reveal the evolutionary foundation of germinal centers
The absence of germinal centers (GCs) in cartilaginous fishes lies at odds with data showing that nurse sharks can produce robust antigen-specific responses and affinity mature their B cell repertoires. To investigate this apparent incongruity, we performed RNA sequencing on single nuclei, allowing...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529500/ https://www.ncbi.nlm.nih.gov/pubmed/37342909 http://dx.doi.org/10.1016/j.celrep.2023.112664 |