A new polymodal gating model of the proton-activated chloride channel

The proton–activated chloride (PAC) channel plays critical roles in ischemic neuron death, but its activation mechanisms remain elusive. Here, we investigated the gating of PAC channels using its novel bifunctional modulator C77304. C77304 acted as a weak activator of the PAC channel, causing modera...

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Detalles Bibliográficos
Autores principales: Zhao, Piao, Tang, Cheng, Yang, Yuqin, Xiao, Zhen, Perez-Miller, Samantha, Zhang, Heng, Luo, Guoqing, Liu, Hao, Li, Yaqi, Liao, Qingyi, Yang, Fan, Dong, Hao, Khanna, Rajesh, Liu, Zhonghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529583/
https://www.ncbi.nlm.nih.gov/pubmed/37713449
http://dx.doi.org/10.1371/journal.pbio.3002309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10529583/
https://www.ncbi.nlm.nih.gov/pubmed/37713449
http://dx.doi.org/10.1371/journal.pbio.3002309

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