Structural insights into the activation of ataxia-telangiectasia mutated by oxidative stress

Ataxia-telangiectasia mutated (ATM) is a master kinase regulating DNA damage response that is activated by DNA double-strand breaks. However, ATM is also directly activated by reactive oxygen species, but how oxidative activation is achieved remains unknown. We determined the cryo-EM structure of an...

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Detalles Bibliográficos
Autores principales: Howes, Anna C., Perisic, Olga, Williams, Roger L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530080/
https://www.ncbi.nlm.nih.gov/pubmed/37756394
http://dx.doi.org/10.1126/sciadv.adi8291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530080/
https://www.ncbi.nlm.nih.gov/pubmed/37756394
http://dx.doi.org/10.1126/sciadv.adi8291

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