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CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and is known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such as neurodegeneration and autoimmune disorders like neuromyelitis optica (NMO). NMO is an astrocyte disease...
Autores principales: | Jiang, Wei, Zhu, Fan, Xu, Huiming, Xu, Li, Li, Haoyang, Yang, Xin, Khan Afridi, Shabbir, Lai, Shuiqing, Qiu, Xiusheng, Liu, Chunxin, Li, Huilu, Long, Youming, Wang, Yuge, Connolly, Kevin, Elias, Jack A., Lee, Chun Geun, Cui, Yaxiong, Huang, Yu-Wen Alvin, Qiu, Wei, Tang, Changyong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530095/ https://www.ncbi.nlm.nih.gov/pubmed/37756391 http://dx.doi.org/10.1126/sciadv.adg8148 |
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