Multi-transcriptomics reveals brain cellular responses to peripheral infection in Alzheimer’s disease model mice

Peripheral inflammation has been linked to various neurodegenerative disorders, including Alzheimer’s disease (AD). Here we perform bulk, single-cell, and spatial transcriptomics in APP/PS1 mice intranasally exposed to Staphylococcus aureus to determine how low-grade peripheral infection affects bra...

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Detalles Bibliográficos
Autores principales: Lu, Yi, Saibro-Girardi, Carolina, Fitz, Nicholas Francis, McGuire, Mikayla Ranae, Ostach, Mary Ann, Mamun-Or-Rashid, A.N.M., Lefterov, Iliya, Koldamova, Radosveta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530196/
https://www.ncbi.nlm.nih.gov/pubmed/37436901
http://dx.doi.org/10.1016/j.celrep.2023.112785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530196/
https://www.ncbi.nlm.nih.gov/pubmed/37436901
http://dx.doi.org/10.1016/j.celrep.2023.112785

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