Enhancing Transcriptional Reprogramming of Mesenchymal Glioblastoma with Grainyhead-like 2 and HDAC Inhibitors Leads to Apoptosis and Cell-Cycle Dysregulation

Glioblastoma (GBM) tumor cells exhibit mesenchymal properties which are thought to play significant roles in therapeutic resistance and tumor recurrence. An important question is whether impairment of the mesenchymal state of GBM can sensitize these tumors to therapeutic intervention. HDAC inhibitor...

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Detalles Bibliográficos
Autores principales: Kotian, Spandana, Carnes, Rachel M., Stern, Josh L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530281/
https://www.ncbi.nlm.nih.gov/pubmed/37761927
http://dx.doi.org/10.3390/genes14091787

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530281/
https://www.ncbi.nlm.nih.gov/pubmed/37761927
http://dx.doi.org/10.3390/genes14091787

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