Glioma Stem Cells Are Sensitized to BCL-2 Family Inhibition by Compromising Histone Deacetylases

Glioblastoma (GBM) remains an incurable disease with an extremely high five-year recurrence rate. We studied apoptosis in glioma stem cells (GSCs) in response to HDAC inhibition (HDACi) combined with MEK1/2 inhibition (MEKi) or BCL-2 family inhibitors. MEKi effectively combined with HDACi to suppres...

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Detalles Bibliográficos
Autores principales: Merati, Aran, Kotian, Spandana, Acton, Alexus, Placzek, William, Smithberger, Erin, Shelton, Abigail K., Miller, C. Ryan, Stern, Josh L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530722/
https://www.ncbi.nlm.nih.gov/pubmed/37761989
http://dx.doi.org/10.3390/ijms241813688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10530722/
https://www.ncbi.nlm.nih.gov/pubmed/37761989
http://dx.doi.org/10.3390/ijms241813688

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